HTF Blog: Prediabetes-Diabetes

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Economic Analysis Model Suggests Screening People for Fibrosis with Non-Invasive Tests Cost-effective

NASH Network (NASHNET), a global network of thought leaders dedicated to advancing care pathways for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), has published a novel cost-effectiveness analysis (CEA) study in Gastroenterology, indicating that screening patients with Type 2 diabetes (T2D) for NAFLD was cost-effective compared with no screening.

Researchers for “Screening for Non-Alcoholic Fatty Liver Disease in Persons with Type 2 Diabetes in the U.S. is Cost Effective: A Comprehensive Cost-Utility Analysis” developed a Markov model to evaluate the cost-effectiveness of six screening strategies, using an incremental, threshold cost-effectiveness ratio of ≤$50,000 per quality-adjusted life year (QALY).

Cost-effective screening approaches observed in the study included the use of ultrasound with or without aspartate aminotransferase (AST) – or alanine aminotransferase (ALT) – to detect possible fibrosis in high-risk patient populations; then, if clinically significant, the deployment of transient elastography (VCTE). VCTE known as FibroScan is a non-invasive technology (NIT) that quickly provides a quantitative assessment of liver stiffness and liver fat at the point of care to make the detection of liver disease and long-term care for individuals with NALFD and NASH more effective.

Patients suspected to have NAFLD or NASH (NASH stage ≥2) were prescribed one year of intensive lifestyle intervention (ILI). Additionally, these screening strategies were found to be cost-effective for T2D patients as young as 40 years of age.

As part of its collaboration with Echosens, NASHNET has been collecting and analyzing data on 6,500 patients over a one-year period. This real-world evidence study is designed to identify cost-effective patient flows to screen, diagnose and manage patients with NAFLD and NASH.  With a goal to create an optimal care delivery model, NASHNET providers utilize FibroScan in primary care, endocrinology and bariatric clinics.  FibroScan provides consistency and evidence and is covered by CMS and most commercial insurance plans for diagnosing and monitoring chronic liver disease.

Battling the Impact of NAFLD

Affecting over 25% of the adult population, NAFLD is the most common form of chronic liver disease in the United States, and the prevalence continues to rise. Approximately 20% of those with NAFLD progress to NASH, the more severe manifestation of the disease, which if left undetected and unmanaged can progress to liver cirrhosis.

As the burden of NAFLD and NASH continues to grow, it has become a financial and population health imperative to define appropriate screening strategies for identifying patients with early stages of liver disease associated with NAFLD to improve overall health, diagnose the disease early, reduce associated financial burden and help inform the development of future professional guidelines.

It is also increasingly important to leverage non-invasive technology (NIT) to identify patients who are at greatest risk of adverse health outcomes or might benefit from early treatment intervention. Recognizing a need for additional cost-effectiveness data regarding the use of NITs, the NASHNET study supplements the growing evidence base demonstrating the utility of NITs for detecting and monitoring NAFLD and NASH.

While liver biopsy remains the gold standard for diagnosing NASH, a number of NITs have emerged in recent years including the ultrasound, AST, ALT, VCTE, controlled attenuation parameter (CAP) and FIB-4.  In this analysis, screening40 approaches that included liver biopsy were not found to be cost effective.

Truckers Confront Risk Factors for Diabetes

“What was really sad for me as a physician was when the poor patient was in the position of having to choose between his health and making a living.” said Larry Wofe, retired Medical Doctor. Jon Slaughter, CEO of Healthy Trucking of America says, “Obesity is the gateway to more severe chronic diseases. Becoming symptomatic to Type 2 Diabetes can be reversed, however a sedentary and stressful profession like trucking doesn’t help.”

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